Abstracts 189

FRIDAY, MARCH 18, 2005

Limburgs Universitair Centrum, Building D, Universitaire Campus, B-3590 Diepenbeek, Belgium

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189th Meeting of the Belgian Society of Biochemistry and Molecular Biology

Local organisers: Marcel Ameloot, Piet Stinissen, Johan Robben (LUC)

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Signaling in the brain

1
Imaging of Inflammatory Regions in the Brain of Rats with Experimental Autoimmune Encephalomyelitis using High Resolution MRI

K. Baeten^1,2 , P. Adriaensens², F. Vandenabeele¹, E. Theunissen¹, J. Gelan² and P. Stinissen¹

Biomedical Rsearch Institute (BIOMED) and 2 Institute of Material Research (IMO), Limburgs Universitair Centrum, Diepenbeek, Belgium

2
Reduced esterase activity is an early marker of apoptosis in oligodendroglial cell lines: flow cytometry and CLSM measurements using calcein-AM and propidium-iodide

Sz. Baron1,2 , E. Gielen1 , I. Smets1 , M. Vandeven1 , P. Steels1 and M. Ameloot1

1 Laboratory of Physiology, Limburgs Universitair Centrum/transnationale Universiteit Limburg, Biomedisch Onderzoeksinstituut, Diepenbeek, Belgium and 2 Department of Botany, Szeged University, Szeged, Hungary

3
Interferon-alpha response in the central nervous system during viral infection

S. Delhaye and T. Michiels.

Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, MIPA-VIRO 74-49, 74, avenue Hippocrate, B-1200, Brussels, Belgium.

4
PLAC24/eIF3k interacts with the human 5-HT_7(a) receptor

K. De Martelaere, B. Lintermans, G. Haegeman and P. Vanhoenacker

Laboratory of Eukaryotic Gene Expression and Signal Transduction, Ghent University - UGent, K. L. Ledeganckstraat 35, 9000 Gent, Belgium.

5
PMF1N: a possible interaction partner of the human 5-HT_7(a) receptor ?

K. De Martelaere, B. Lintermans, G. Haegeman and P. Vanhoenacker

Laboratory of Eukaryotic Gene Expression and Signal Transduction, Ghent University - UGent, K. L. Ledeganckstraat 35, 9000 Gent, Belgium.

6
CREB is involved in the mitochondrial dysfunction-induced gene expression modifications and triglyceride accumulation.

A. De Pauw*, S. Vankoningsloo*, A. Houbion*, E. Delaive*, S. Tejerina*, F. De Longueville§, P. Renard*, M. Raes* and T. Arnould*.

* : Laboratoire de Biochimie et Biologie Cellulaire, University of Namur (F.U.N.D.P), 61 rue de Bruxelles, 5000 Namur, Belgium; § : Eppendorf Array Technologies, 20 rue du séminaire, 5000 Namur, Belgium.

7
Characterization of the multiple sclerosis CSF proteome and identification of potential disease markers

D. Dumont, J.-P. Noben, P. Stinissen, J. Raus and J. Robben

Biomedisch Onderzoeksinstituut (BIOMED), Limburgs Universitair Centrum and School of Life Sciences, Transnational University Limburg, Diepenbeek, Belgium

8
In vivo long-term cell marking of neural stem cells in adult rodent brain by lentiviral vectors.

1 M. Geraerts, C. Vallejo, 1 S. Willems, 2 V. Baekelandt and 1 Z. Debyser

1 Laboratory for Molecular Virology and Gene Therapy, KULeuven and KULAK, Flanders, Belgium. 2 Laboratory for Neurobiology and Gene Therapy, KULeuven, Flanders, Belgium

9
Study of the membrane organization of OLN-93 oligodendroglial cells by means of fluorescence correlation spectroscopy: raft versus non-raft

E. Gielen 1 , J. Sykora 2 , J. Humpolickova 2 , J. Vercammen 3 , M. Vandeven 1 , A. Benda 2 , N. Hellings 1 , M. Hof 2 , Y. Engelborghs 3 , P. Steels 1 and M. Ameloot 1.

1 Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum (LUC) and transnationale Universiteit Limburg (tUL), Universitaire Campus Bldg. D and A, B-3590 Diepenbeek, Belgium; 2 J. Heyrovský Institute of Physical Chemistry, Acad. of Sciences of the Czech Republic, Dolej?kova 3, Cz-18223, Prague 8, Czech Republic; 3 Biochemistry Department, K.U.Leuven, Celestijnenlaan 200D, B-3001 Heverlee, Belgium.

10
Identification of new molecular markers for multiple sclerosis using phage cDNA display

C. Govarts, K. Somers, P. Stinissen and V. Somers

Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum and School of Life Sciences, Transnational University Limburg, Diepenbeek, Belgium

11
No Association of Leukemia Inhibitory Factor (LIF) DNA Polymorphisms with Multiple Sclerosis

N. Hellings, J. Vanderlocht, J. Bleus, J. Raus and P. Stinissen
Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum, Diepenbeek, Belgium

12
Flavonoids Influence Monocytic GTPase Activity and Are Protective in Experimental Allergic Encephalitis

J. J..A. Hendriks 1# , J. Alblas 1 , S. M.A. Van Der Pol 1 , E. A.F. Van Tol 2 , C. D. Dijkstra 1 , and H. E. De Vries 1

1 Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center (VUMC), 1007 MB Amsterdam, Netherlands. Phone: +31-20-444-8077; Fax: +31-20-444-8081; # New address: Biomedical Research Institute (BIOMED), Limburgs Universitair Centrum, University Campus, B-3590 Diepenbeek, Belgium. 2 Biomedical Research Department, Numico Research B.V., 6704 PH Wageningen, Netherlands

13
Conditional knockout of peroxisomes in the brain

L. Hulshagen 1 , O. Krysko 1 , S. Huyghe 1 , R. D'hooge 2 , P. P. De Deyn 2 and M. Baes 1

1 Laboratory of Clinical Chemistry, K.U.Leuven, Leuven, Belgium and 2 Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium

14
Liver peroxisomes are necessary for cortical neuronal migration and normal development of the cerebellum.

O. Krysko 1 ; P. Gressens 3 ; M. Espeel 2 and M. Baes 1

1 Laboratory of Clinical Chemistry, K.U. Leuven, 2 Department of Human Anatomy, Embryology, Histology and Medical Physics, Ghent University, Belgium and 3 Laboratory of Developmental Neurology, Hospital Robert-Debré, Paris, France

15
Cloning and characterization of three mouse 5-HT₇ receptor splice variants

K. Laenen, K. De Martelaere, A. Matthys, B. Lintermans, G. Haegeman and P. Vanhoenacker

Laboratory of Eukaryotic Gene Expression and Signal Transduction, Ghent University - UGent, K. L. Ledeganckstraat 35, 9000 Gent, Belgium.

16
Non-invasive imaging of neuropathology in a rat model for Parkinson's disease based on overexpression of alpha-synuclein

E Lauwers 1 , D. Bequé 2 , K. Van Laere 2 , J. Nuyts 2 , G. Bormans 3 , L. Mortelmans 2 , L. Vercammen 1 , O. Bockstael 6 , B. Nuttin 4 , Z. Debyser 5 and V. Baekelandt 1

1 Laboratory for Neurobiology and Gene Therapy, 2 Division of Nuclear Medicine, University Hospital Leuven, 3 Laboratory for Radiopharmaceutical Chemistry, 4 Laboratory for Experimental Neurosurgery and Neuroanatomy, 5 Laboratory for Molecular Virology and Gene Therapy; K.U.Leuven, Leuven, Belgium 6 Laboratory of Experimental Neurosurgery, Institute of Interdisciplinary Research, Faculty of Medicine, Université Libre de Bruxelles

17
Synovial Fluid NKT Cells Display Different Properties Compared to Peripheral Blood NKT Cells in Rheumatoid Arthritis

L. Linsen, M. Thewissen , V. Somers, P. Geusens, J. Raus and P. Stinissen

Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum, Diepenbeek, Belgium

18
Measuring protein-protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75.

G. Maertens 1,2 , J. Vercammen 1,2 , Z. Debyser 2 and Y. Engelborghs 1

1 Laboratory of Biomolecular Dynamics, Katholieke Universiteit Leuven, and 2 Molecular Virology and Gene Therapy, Katholieke Universiteit Leuven

19
TGF-_1 mediates the organization and expression of cytoskeletal proteins in astrocytes

M. Moreels, F. Vandenabeele, D. Dumont, J. Robben and I. Lambrichts

Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum and School of Life Sciences, Transnational University Limburg, University Campus, Diepenbeek, Belgium.

20
Reversal of mitochondrial Na/Ca exchangers in metabolically inhibited MDCK cells: confocal microscopic study of mitochondrial calcium and sodium

I. Smets 1 , Sz. Baron 1,2 , A. Caplanusi 3, , Zs. Molnar 2 , M. Radu 4 , M. vandeVen 1 , M. Ameloot 1 and P. Steels 1

1 Limburgs Universitair Centrum/transnationale Universiteit Limburg -Biomedical Research Institute , Diepenbeek, Belgium; 2 University of Szeged, Szeged, Hungary; 3 Carol Davila University of Medicine and Pharmacy, Bucharest, Romania and 4 Horia Hulubei National Institute for Physics and Nuclear Engineering, Bucharest, Romania

21
The hypothalamic AMPK-mediated stimulation of food intake is lacking in Lou/C rats, a strain resistant to obesity

N. Taleux 1, 2 , B. Guigas 1 , G. Lacraz 2 , R. Favier 2 , X. Leverve 2 and L. Hue 1

1 Hormone and Metabolic Research Unit, Institut of Cellular Pathology, University of Louvain Medical School, Brussels, Belgium ; 2 Laboratory of Fundamental and Applied Bioenergetic, University of Joseph Fourier, Grenoble, France.

22
Study of the hTERT Expression in PBMC of Rheumatoid Arthritis Patients

M. Thewissen, L. Linsen, P. Geusens, J. Raus and P. Stinissen

Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum (LUC) and transnational University Limburg (tUL), Universitaire Campus building A, Diepenbeek, Belgium

23
Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis

K. Van Craenenbroeck 1,2 , S Clark 2 , G. Haegeman 1 , P. Vanhoenacker 1 and H.H.M. Van Tol 2

1 Laboratory of Molecular Biology, Ghent University, Gent, Belgium; 2 Laboratory of Molecular Neurobiology, Centre for Addiction and Mental Health, Toronto, Canada

24
Expression of a specific calcium-binding protein of the S100 protein family, S100A6 (calcyclin) in multiple sclerosis plaques.

F. Vandenabeele, M. Moreels, I. Lambrichts, M. Ameloot, and P. Stinissen

Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum and School of Life Sciences, Transnational University Limburg, University Campus, Diepenbeek, Belgium.

25
Leukemia inhibitory factor is produced by myelin reactive T-cells and protects against cytokine induced oligodendrocyte cell death

J. Vanderlocht 1 , N. Hellings 1 , F. Vandenabeele 1 , M. Moreels 1 , M. Buntinx 1 , Jp. Antel 2 , J. Raus 1 and P. Stinissen 1

Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum, Diepenbeek, Belgium, and *Montreal Neurological Institute, McGill University, Montreal, Canada

26
On the presence of N-acetyl-sphingenine (C₂-ceramide) in mammalian brain, possible relationship to etherphospholipids and phosphorylation by ceramide kinase.

H. Van Overloop, M. Baes* and P.P. Van Veldhoven

Afdeling Farmacologie, Faculteit Geneeskunde and *Labo Klinische Chemie, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Belgium.

27
CD4⁺ CD25⁺ regulatory T cells isolated from patients with relapsing-remitting multiple sclerosis show an impaired suppressive capacity and reduced FOXP3 expression

K. Venken 1 , N. Hellings 1 , K. Hensen 2 , J.-L. Rummens 2 , R. Medaer 1 , J. Raus 1 and P. Stinissen 1

1 Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum and School of Life Sciences, Transnational University Limburg, Diepenbeek, Belgium; 2 Clinical Laboratory of Experimental Hematology, Virga Jesse Hospital, Hasselt, Belgium

28
Modulation of Trp53 dependent and independent transcripts in the X-ray irradiated developing mouse brain.

J. Verheyde 1,2 , L. de Saint-Georges 1 , L. Leyns 2 , M. Mergeay 1 and M.A. Benotmane 1

1 Laboratory of Radiobiology, Belgian Nuclear Research Centre (SCK · CEN), Boeretang 200, Mol B-2400, Belgium and 2 Laboratory for Cellular Genetics, Free University of Brussels (VUB), Pleinlaan 2, Brussel B-1000, Belgium

29
The presence of four iron-containing superoxide dismutase isozymes in Trypanosomatidae : characterization and subcellular localization in Trypanosoma brucei.

C. Yernaux 1 , D. Gerbod 2 , F. R. Opperdoes 1 and E. Viscogliosi 2 .

1 Christian de Duve Institute of Cellular Pathology, B-1200 Brussels, Belgium and 2 Institut Pasteur, Inserm U547, F-59019 Lille cedex, France

	Signaling in the brain
1	Imaging of Inflammatory Regions in the Brain of Rats with Experimental Autoimmune Encephalomyelitis using High Resolution MRI K. Baeten^1,2 , P. Adriaensens², F. Vandenabeele¹, E. Theunissen¹, J. Gelan² and P. Stinissen¹ Biomedical Rsearch Institute (BIOMED) and 2 Institute of Material Research (IMO), Limburgs Universitair Centrum, Diepenbeek, Belgium
2	Reduced esterase activity is an early marker of apoptosis in oligodendroglial cell lines: flow cytometry and CLSM measurements using calcein-AM and propidium-iodide Sz. Baron1,2 , E. Gielen1 , I. Smets1 , M. Vandeven1 , P. Steels1 and M. Ameloot1 1 Laboratory of Physiology, Limburgs Universitair Centrum/transnationale Universiteit Limburg, Biomedisch Onderzoeksinstituut, Diepenbeek, Belgium and 2 Department of Botany, Szeged University, Szeged, Hungary
3	Interferon-alpha response in the central nervous system during viral infection S. Delhaye and T. Michiels. Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, MIPA-VIRO 74-49, 74, avenue Hippocrate, B-1200, Brussels, Belgium.
4	PLAC24/eIF3k interacts with the human 5-HT_7(a) receptor K. De Martelaere, B. Lintermans, G. Haegeman and P. Vanhoenacker Laboratory of Eukaryotic Gene Expression and Signal Transduction, Ghent University - UGent, K. L. Ledeganckstraat 35, 9000 Gent, Belgium.
5	PMF1N: a possible interaction partner of the human 5-HT_7(a) receptor ? K. De Martelaere, B. Lintermans, G. Haegeman and P. Vanhoenacker Laboratory of Eukaryotic Gene Expression and Signal Transduction, Ghent University - UGent, K. L. Ledeganckstraat 35, 9000 Gent, Belgium.
6	CREB is involved in the mitochondrial dysfunction-induced gene expression modifications and triglyceride accumulation. A. De Pauw, S. Vankoningsloo, A. Houbion, E. Delaive, S. Tejerina, F. De Longueville§, P. Renard, M. Raes* and T. Arnould. : Laboratoire de Biochimie et Biologie Cellulaire, University of Namur (F.U.N.D.P), 61 rue de Bruxelles, 5000 Namur, Belgium; § : Eppendorf Array Technologies, 20 rue du séminaire, 5000 Namur, Belgium.
7	Characterization of the multiple sclerosis CSF proteome and identification of potential disease markers D. Dumont, J.-P. Noben, P. Stinissen, J. Raus and J. Robben Biomedisch Onderzoeksinstituut (BIOMED), Limburgs Universitair Centrum and School of Life Sciences, Transnational University Limburg, Diepenbeek, Belgium
8	In vivo long-term cell marking of neural stem cells in adult rodent brain by lentiviral vectors. 1 M. Geraerts, C. Vallejo, 1 S. Willems, 2 V. Baekelandt and 1 Z. Debyser 1 Laboratory for Molecular Virology and Gene Therapy, KULeuven and KULAK, Flanders, Belgium. 2 Laboratory for Neurobiology and Gene Therapy, KULeuven, Flanders, Belgium
9	Study of the membrane organization of OLN-93 oligodendroglial cells by means of fluorescence correlation spectroscopy: raft versus non-raft E. Gielen 1 , J. Sykora 2 , J. Humpolickova 2 , J. Vercammen 3 , M. Vandeven 1 , A. Benda 2 , N. Hellings 1 , M. Hof 2 , Y. Engelborghs 3 , P. Steels 1 and M. Ameloot 1. 1 Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum (LUC) and transnationale Universiteit Limburg (tUL), Universitaire Campus Bldg. D and A, B-3590 Diepenbeek, Belgium; 2 J. Heyrovský Institute of Physical Chemistry, Acad. of Sciences of the Czech Republic, Dolej?kova 3, Cz-18223, Prague 8, Czech Republic; 3 Biochemistry Department, K.U.Leuven, Celestijnenlaan 200D, B-3001 Heverlee, Belgium.
10	Identification of new molecular markers for multiple sclerosis using phage cDNA display C. Govarts, K. Somers, P. Stinissen and V. Somers Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum and School of Life Sciences, Transnational University Limburg, Diepenbeek, Belgium
11	No Association of Leukemia Inhibitory Factor (LIF) DNA Polymorphisms with Multiple Sclerosis N. Hellings, J. Vanderlocht, J. Bleus, J. Raus and P. Stinissen Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum, Diepenbeek, Belgium
12	Flavonoids Influence Monocytic GTPase Activity and Are Protective in Experimental Allergic Encephalitis J. J..A. Hendriks 1# , J. Alblas 1 , S. M.A. Van Der Pol 1 , E. A.F. Van Tol 2 , C. D. Dijkstra 1 , and H. E. De Vries 1 1 Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center (VUMC), 1007 MB Amsterdam, Netherlands. Phone: +31-20-444-8077; Fax: +31-20-444-8081; # New address: Biomedical Research Institute (BIOMED), Limburgs Universitair Centrum, University Campus, B-3590 Diepenbeek, Belgium. 2 Biomedical Research Department, Numico Research B.V., 6704 PH Wageningen, Netherlands
13	Conditional knockout of peroxisomes in the brain L. Hulshagen 1 , O. Krysko 1 , S. Huyghe 1 , R. D'hooge 2 , P. P. De Deyn 2 and M. Baes 1 1 Laboratory of Clinical Chemistry, K.U.Leuven, Leuven, Belgium and 2 Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium
14	Liver peroxisomes are necessary for cortical neuronal migration and normal development of the cerebellum. O. Krysko 1 ; P. Gressens 3 ; M. Espeel 2 and M. Baes 1 1 Laboratory of Clinical Chemistry, K.U. Leuven, 2 Department of Human Anatomy, Embryology, Histology and Medical Physics, Ghent University, Belgium and 3 Laboratory of Developmental Neurology, Hospital Robert-Debré, Paris, France
15	Cloning and characterization of three mouse 5-HT₇ receptor splice variants K. Laenen, K. De Martelaere, A. Matthys, B. Lintermans, G. Haegeman and P. Vanhoenacker Laboratory of Eukaryotic Gene Expression and Signal Transduction, Ghent University - UGent, K. L. Ledeganckstraat 35, 9000 Gent, Belgium.
16	Non-invasive imaging of neuropathology in a rat model for Parkinson's disease based on overexpression of alpha-synuclein E Lauwers 1 , D. Bequé 2 , K. Van Laere 2 , J. Nuyts 2 , G. Bormans 3 , L. Mortelmans 2 , L. Vercammen 1 , O. Bockstael 6 , B. Nuttin 4 , Z. Debyser 5 and V. Baekelandt 1 1 Laboratory for Neurobiology and Gene Therapy, 2 Division of Nuclear Medicine, University Hospital Leuven, 3 Laboratory for Radiopharmaceutical Chemistry, 4 Laboratory for Experimental Neurosurgery and Neuroanatomy, 5 Laboratory for Molecular Virology and Gene Therapy; K.U.Leuven, Leuven, Belgium 6 Laboratory of Experimental Neurosurgery, Institute of Interdisciplinary Research, Faculty of Medicine, Université Libre de Bruxelles
17	Synovial Fluid NKT Cells Display Different Properties Compared to Peripheral Blood NKT Cells in Rheumatoid Arthritis L. Linsen, M. Thewissen , V. Somers, P. Geusens, J. Raus and P. Stinissen Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum, Diepenbeek, Belgium
18	Measuring protein-protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75. G. Maertens 1,2 , J. Vercammen 1,2 , Z. Debyser 2 and Y. Engelborghs 1 1 Laboratory of Biomolecular Dynamics, Katholieke Universiteit Leuven, and 2 Molecular Virology and Gene Therapy, Katholieke Universiteit Leuven
19	TGF-_1 mediates the organization and expression of cytoskeletal proteins in astrocytes M. Moreels, F. Vandenabeele, D. Dumont, J. Robben and I. Lambrichts Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum and School of Life Sciences, Transnational University Limburg, University Campus, Diepenbeek, Belgium.
20	Reversal of mitochondrial Na/Ca exchangers in metabolically inhibited MDCK cells: confocal microscopic study of mitochondrial calcium and sodium I. Smets 1 , Sz. Baron 1,2 , A. Caplanusi 3, , Zs. Molnar 2 , M. Radu 4 , M. vandeVen 1 , M. Ameloot 1 and P. Steels 1 1 Limburgs Universitair Centrum/transnationale Universiteit Limburg -Biomedical Research Institute , Diepenbeek, Belgium; 2 University of Szeged, Szeged, Hungary; 3 Carol Davila University of Medicine and Pharmacy, Bucharest, Romania and 4 Horia Hulubei National Institute for Physics and Nuclear Engineering, Bucharest, Romania
21	The hypothalamic AMPK-mediated stimulation of food intake is lacking in Lou/C rats, a strain resistant to obesity N. Taleux 1, 2 , B. Guigas 1 , G. Lacraz 2 , R. Favier 2 , X. Leverve 2 and L. Hue 1 1 Hormone and Metabolic Research Unit, Institut of Cellular Pathology, University of Louvain Medical School, Brussels, Belgium ; 2 Laboratory of Fundamental and Applied Bioenergetic, University of Joseph Fourier, Grenoble, France.
22	Study of the hTERT Expression in PBMC of Rheumatoid Arthritis Patients M. Thewissen, L. Linsen, P. Geusens, J. Raus and P. Stinissen Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum (LUC) and transnational University Limburg (tUL), Universitaire Campus building A, Diepenbeek, Belgium
23	Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis K. Van Craenenbroeck 1,2 , S Clark 2 , G. Haegeman 1 , P. Vanhoenacker 1 and H.H.M. Van Tol 2 1 Laboratory of Molecular Biology, Ghent University, Gent, Belgium; 2 Laboratory of Molecular Neurobiology, Centre for Addiction and Mental Health, Toronto, Canada
24	Expression of a specific calcium-binding protein of the S100 protein family, S100A6 (calcyclin) in multiple sclerosis plaques. F. Vandenabeele, M. Moreels, I. Lambrichts, M. Ameloot, and P. Stinissen Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum and School of Life Sciences, Transnational University Limburg, University Campus, Diepenbeek, Belgium.
25	Leukemia inhibitory factor is produced by myelin reactive T-cells and protects against cytokine induced oligodendrocyte cell death J. Vanderlocht 1 , N. Hellings 1 , F. Vandenabeele 1 , M. Moreels 1 , M. Buntinx 1 , Jp. Antel 2 , J. Raus 1 and P. Stinissen 1 Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum, Diepenbeek, Belgium, and Montreal Neurological Institute, McGill University, Montreal, Canada*
26	On the presence of N-acetyl-sphingenine (C₂-ceramide) in mammalian brain, possible relationship to etherphospholipids and phosphorylation by ceramide kinase. H. Van Overloop, M. Baes* and P.P. Van Veldhoven Afdeling Farmacologie, Faculteit Geneeskunde and Labo Klinische Chemie, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Belgium.*
27	CD4⁺ CD25⁺ regulatory T cells isolated from patients with relapsing-remitting multiple sclerosis show an impaired suppressive capacity and reduced FOXP3 expression K. Venken 1 , N. Hellings 1 , K. Hensen 2 , J.-L. Rummens 2 , R. Medaer 1 , J. Raus 1 and P. Stinissen 1 1 Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum and School of Life Sciences, Transnational University Limburg, Diepenbeek, Belgium; 2 Clinical Laboratory of Experimental Hematology, Virga Jesse Hospital, Hasselt, Belgium
28	Modulation of Trp53 dependent and independent transcripts in the X-ray irradiated developing mouse brain. J. Verheyde 1,2 , L. de Saint-Georges 1 , L. Leyns 2 , M. Mergeay 1 and M.A. Benotmane 1 1 Laboratory of Radiobiology, Belgian Nuclear Research Centre (SCK · CEN), Boeretang 200, Mol B-2400, Belgium and 2 Laboratory for Cellular Genetics, Free University of Brussels (VUB), Pleinlaan 2, Brussel B-1000, Belgium
29	*The presence of four iron-containing superoxide dismutase isozymes in Trypanosomatidae : characterization and subcellular localization in Trypanosoma brucei.* C. Yernaux 1 , D. Gerbod 2 , F. R. Opperdoes 1 and E. Viscogliosi 2 . 1 Christian de Duve Institute of Cellular Pathology, B-1200 Brussels, Belgium and 2 Institut Pasteur, Inserm U547, F-59019 Lille cedex, France